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Our History
Founder & CEO
Our History
As a young boy growing up in rural India, most of what I knew of the world was what I could see around me. But each night, I would look at the Moon...
Founder & CEO
Founder & CEO
Founder & CEO
NATURE INDIA | INDIGENUS
Away from home: Using science for societal good
Publications
- Mattapally S, Z Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J.. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. doi: 10.1161/JAHA.118.010239.
- Mattapally S, Zhu W, Fast VG, Gao L, Worley C, Kannappan R, Borovjagin A, Zhang J. Spheroids of cardiomyocytes derived from human induced-pluripotent stem cells improve recovery from myocardial injury in mice. Am J Physiol Heart Circ Physiol. 2018 Aug 1;315 (2):H327-H339. https://doi.org/10.1152/ajpheart.00688.2017
- Mattapally S, Singh M, Murthy KS, Asthana S, Banerjee SK. Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation. Oncotarget 2018_ 9 (17), 13713. doi: 10.18632/oncotarget.24459
- Zhao M , Fan C, Ernst PJ , Tang Y, Zhub H , Mattapally S , Oduk Y , Borovjagin AV , Zhou L , Zhang J, , Zhu W. Y-27632 Preconditioning Enhances Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarction Mice. Cardiovascular Research, cvy207,https://doi.org/10.1093/cvr/cvy207.
- Gao L, Gregorich Z, Zhu W, Mattapally S, Oduk Y, lou X, Kannappan R, Borovjagin A, Walcott G, Pollard A, Fast V, Hu X, Lloud SG, Ge Y, Zhang J: Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cell derived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine. Circulation 2017.137(16):1712-1730.DOI: 10.1161/CIRCULATIONAHA.117.030785
- Zhu W, Zhao M, Mattapally S, Zhang J: CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circulation Research. 2017;122:88-96. doi: 10.1161/CIRCRESAHA.117.311504
- Mattapally S, Nizamuddin S, Murthy KS, Thangaraj K, Banerjee SK. c.620C>T mutation in GATA4 is associated with congenital heart disease in South India. BMC Medical Genetics 2015, 16:7.https://doi.org/10.1186/s12881-015-0152-7
- Mattapally S, Banerjee SK: Nitric oxide: Redox balance, protein modification and therapeutic potential in cardiovascular system. IIOAB Journal 2011, 2:29-38.doi=10.1.1.674.960&rep=rep1&type=pdf.
- Kannappan R, Mattapally S, Pooja S, Zhang J. Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells. AJP-Heart and Circ-2018 (In Press).https://doi.org/10.1152/ajpheart.00160.2018.
- Pala RS, Pathipati UR, Mattapally S, Banerjee SK. Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus aureus disease in silkworm model. Materials Science and Engineering, 2017: C 77, 990-1002.https://doi.org/10.1016/j.msec.2017.04.026
- Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK. Attenuation of Insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacological Research, 2012, 66(3): 260-268.https://doi.org/10.1016/j.phrs.2012.05.003
- Adela R, Nethi SK, Bagul PK, Barui AK, Mattapally S, Kuncha M, Patra CR, Reddy PN, Banerjee SK. Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A study from Indian Patients. PLoS One. 2015 Apr 20;10(4). https://doi.org/10.1371/journal.pone.0125270
- Nethi SK, Veeriah V, Barui AK, Rajendran S, Mattapally S, Misra S, Chatterjee S and Patra CR. Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale. 2015,7, 9760-9770.doi: 10.1039/c5nr01327e
- Santhoshi A, Mahendar B, Mattapally S, Sadhua P, Banerjee SK, Rao VJ. Synthesis of Thio-HeterocyclicAnaloguesfrom Baylis-Hillmann Bromides as Potent Cyclooxygenase-2 Inhibitors. Bioorg Med Chem Lett, 2014, 24 (8), 1952-1957. https://doi.org/10.1016/j.bmcl.2014.02.073
- Ravinder M, Mahendar B, Mattapally S, Hamsini KV, Reddy TN, Rohit C, Srinivas K, Banerjee SK, Rao VJ. Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiestarase3 (PDE3): A target for heart failure and platelet aggregation. Bioorg Med Chem Lett, 2012, 22(18): 6010-6015.https://doi.org/10.1016/j.bmcl.2012.05.019
Abstract in Journals:
- Mattapally S, Zhang J. hiPSC of CIITA and B2M KO Derived Cardiac Cells Engineered 3D Spheroid Transplantation Induce Tachycardia in Myocardial Infarction in Swine. Circulation 142 (Suppl_3), A13381-A13381. https://www.ahajournals.org/doi/abs/10.1161/circ.142.suppl_3.13381
- Mattapally S, E Zhang E, Fast VG, Pollard AE, Mattapally C, Zhang J. CRISPR Guide RNA Design is Able to Use for Studying Splicing and Circadian Gene Expression. Circulation. 2021;144:A13426. https://www.ahajournals.org/doi/abs/10.1161/circ.144.suppl_1.13426
- Mattapally S, Antony VB. Computational Modeling of Aldehyde Dehydrogenase 2 (ALDH2) a Marker for Damaged Mitochondria in Extracellular Vesicles of EVALI. TP083 Hey jude-novel findings from omic and bioinformatic approaches in pulmonary hypertension, Am J Respir Crit Care Med 2021;203: A3626. https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A3626
- Mattapally S, Surolia R, Li FJ, Wang Z, Guo Y, Antony VB. Role of Peptidyl Arginine Deiminases in the Pathogenesis of Calcified Pleural Plaque Formation Following Asbestos Exposure. A39 - Diagnosis and Treatment In Pleural Disease, Am J Respir Crit Care Med 2020;201: A1572. https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2020.201.1_MeetingAbstracts.A1572
- Mattapally S, Z Mattapally S, Pawlik KM, Fast VG Zhang J. HLA Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Regeneration. Circulation 138 (Suppl_1), A13210- A13210.https://www.ahajournals.org/doi/abs/10.1161/circ.138.suppl_1.13210
- Mattapally S, Zhu W, Fast VG, Worley C, Gao L, Kannappan R, Zhang J. A Scaffold Free 3D Spheroid tissue derived from hipsc-differentiated cardiomyocytes for myocardial infarction therapy applications. Circulation, 136 (Suppl 1), A20877-A20877.doi/abs/10.1161/circ.136.suppl_1.20877
- Zhu W, Zhao M, Mattapally S, Zhang J: Cyclin-D2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes. Circulation 136 (Suppl 1), A18679-A18679.doi/10.1161/circ.136.suppl_1.18679
- LaBarge W, Mattapally S, Berry J, Zhang J. Development of a Scaffold-Free, Three Dimensional Bioprinter that Utilizes Cellular Spheroids. 2017 BMES Annual Meeting, USA.
- Kannappan R, Mattapally S, Zhu W, Zhang J. Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells. Circulation, 2016, 134 (Suppl 1), A19566-A19566.doi/10.1161/circ.134.suppl_1.19566
- Zhu W, Zhao M, Mattapally S, Gao L, Zhang J: Cell Cycle Activation of Cardiomyocytes Derived From Induced Pluripotent Stem Cells for Cardiac Regeneration. Circulation Research, 2016, 119 (Suppl 1), A41-A41.doi/10.1161/res.119.suppl_1.41
- Mattapally S, Murthy KS, Nizamuddin S, Thangaraj K, Banerjee SK; (Abstract/Program # 2039S) Novel NKX2.5 mutation associated with congenital heart disease in south Indian patients. American Society of Human Genetics, October 19, 2014 in San Diego, CA. abstracts/fulltext/f140121487.htm
- Mattapally S., Murthy KS., Nizamuddin S., Thangaraj K., Banerjee SK; (Abstract/Program #2722T) Novel GATA4 promoter polymorphism associated with congenital heart disease in south Indian patients. American Society of Human Genetics, October 23, 2013 in Boston, MA.abstracts/fulltext/f130121691.htm
- Mattapally S, Adela R, Rao V, Kona SM, Banerjee SK: Congenital heart disease: its prevalence and importance in Indian population. IJPPAZ 55 (5) 1-336 (2011),ISSN 0019-5499.
Patent Granted/Filed (US, French & India):
1. Mahendar B, Mattapally S, Ravinder M, Banerjee SK, Rao VJ. Pyridopyrimidine based derivatives as potential phosphodiesterase 3 (pde3) inhibitors and a process for the preparation thereof. US Patent App. 14/168,411, 2014.( US20140221651 A1 ) patent/US9242982B2/en
2. Mahendar B, Mattapally S, Ravinder M, Banerjee SK, Rao VJ. Indolizinone based derivatives as potential phosphodiesterase 3 (pde3) inhibitors and a process for the preparation thereof. US Patent App. 14/168,370, 2014.( US20140296530 A1 ) patent/US9249139B2/en
3. Mahendar B, Mattapally S, Ravinder M, Banerjee SK, Rao VJ. Pyridopyrimidine based derivatives as potential phosphodiesterase 3 (pde3) inhibitors and a process for the preparation thereof. IN Patent App. 287/DEL/2013.
4. Mahendar B, Mattapally S, Ravinder M, Banerjee SK, Rao VJ. Indolizinone based derivatives as potential phosphodiesterase 3 (pde3) inhibitors and a process for the preparation thereof. IN Patent App. 288/DEL/2013.
5. G. Jagadeesh KUMAR, B. Mahendar, M. Saidulu, S K Banerjee, V. Jayathirtha RAO. 2-pyridone based compounds useful as potential phosphodiesterase3a (pde3a) inhibitors and a process for the preparation thereof. WO2017072796A1 (USA, French). patent/WO2017072796A1/en
Book Chapter:
1. Mattapally S, Cukier-Meisner W.K, Zhang J. (2017) Differentiation and Use of Induced Pluripotent Stem Cells for Cardiovascular Therapy and Tissue Engineering. In: Ieda M., Zimmermann WH. (eds) Cardiac Regeneration. Cardiac and Vascular Biology. Springer. DOI https://doi.org/10.1007/978-3-319-56106-6_5.
Projects
I am currently worked on the project “COVID-19 role immunosuppresion and arrhythmias in solid-organ transplant recipient.”
The project involves understanding the clinical highlights and results of COVID-19 among immunosuppressed patients, who are at assumed risk of more serious infection.....
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